group namespace name nOverlap adjp members_Overlap 0-0-0-1-0-0 (MTr) Organismal Systems Thermogenesis 93 7.7e-30 Acsl1, Acsl6, Adcy5, Adcy8, Adcy9, Atp5a1, Atp5b, Atp5c1, Atp5d, Atp5g1, Atp5g3, Atp5h, Atp5j, Atp5k, Atp5o, Atp5pb, Coa7, Cox10, Cox11, Cox14, Cox4i1, Cox4i2, Cox5a, Cox6a2, Cox7a1, Cox8b, Cpt1b, Cpt2, Cyc1, Dpf3, Mgll, mt-Cytb, mt-Nd1, mt-Nd2, mt-Nd5, mt-Nd6, Ndufa1, Ndufa10, Ndufa11, Ndufa12, Ndufa13, Ndufa2, Ndufa4, Ndufa5, Ndufa6, Ndufa8, Ndufa9, Ndufab1, Ndufaf1, Ndufaf4, Ndufaf6, Ndufaf7, Ndufb10, Ndufb11, Ndufb2, Ndufb3, Ndufb4, Ndufb4c, Ndufb5, Ndufb6, Ndufb7, Ndufb8, Ndufb9, Ndufc1, Ndufs1, Ndufs2, Ndufs3, Ndufs4, Ndufs5, Ndufs6, Ndufs7, Ndufs8, Ndufv1, Ndufv2, Ndufv3, Ppargc1a, Prdm16, Prkaa2, Prkag3, Rps6ka2, Sdha, Sdhb, Sdhc, Sdhd, Slc25a20, Slc25a29, Smarcd1, Uqcr11, Uqcrb, Uqcrc1, Uqcrc2, Uqcrfs1, Uqcrq 0-0-0-1-0-0 (MTr) Organismal Systems Retrograde endocannabinoid signaling 47 1e-14 Adcy5, Adcy8, Adcy9, Cacna1s, Gabrr2, Gnb3, Mgll, mt-Nd1, mt-Nd2, mt-Nd5, mt-Nd6, Ndufa1, Ndufa10, Ndufa11, Ndufa12, Ndufa13, Ndufa2, Ndufa4, Ndufa5, Ndufa6, Ndufa8, Ndufa9, Ndufab1, Ndufb10, Ndufb11, Ndufb2, Ndufb3, Ndufb4, Ndufb4c, Ndufb5, Ndufb6, Ndufb7, Ndufb8, Ndufb9, Ndufc1, Ndufs1, Ndufs2, Ndufs3, Ndufs4, Ndufs5, Ndufs6, Ndufs7, Ndufs8, Ndufv1, Ndufv2, Ndufv3, Slc17a7 0-0-0-1-0-0 (MTr) Organismal Systems Cardiac muscle contraction 31 8.7e-10 Actc1, Asph, Atp1a2, Atp1b2, Atp2a2, Cacna1s, Cacna2d1, Cacnb2, Cacng6, Casq2, Cox4i1, Cox4i2, Cox5a, Cox6a2, Cox7a1, Cox8b, Cyc1, Hrc, mt-Cytb, Myh6, Myl2, Myl3, Tnnc1, Tnni3, Trdn, Uqcr11, Uqcrb, Uqcrc1, Uqcrc2, Uqcrfs1, Uqcrq 0-0-0-1-0-0 (MTr) Environmental Process Neuroactive ligand-receptor interaction 27 0.0018 Adra1a, Adra1d, Adra2b, Adrb1, Agtr1a, Apln, Aplnr, Avp, Chrna10, Crhr2, Edn3, Gabrr2, Ghr, Grin2c, Grin3b, Nmb, Npy4r, P2rx6, P2ry1, Penk, Prlr, S1pr5, Sstr3, Tac1, Thra, Thrb, Vipr2 0-0-0-1-0-0 (MTr) Organismal Systems PPAR signaling pathway 15 0.015 Acadl, Acadm, Acsl1, Acsl6, Cd36, Cpt1b, Cpt2, Ehhadh, Fabp3, Lpl, Me1, Me3, Plin5, Ppara, Rxrg 0-0-0-1-0-0 (MTr) Organismal Systems Adrenergic signaling in cardiomyocytes 26 0.016 Actc1, Adcy5, Adcy8, Adcy9, Adra1a, Adra1d, Adrb1, Agtr1a, Atp1a2, Atp1b2, Atp2a2, Cacna1s, Cacna2d1, Cacnb2, Cacng6, Camk2a, Kcne1, Myh6, Myl2, Myl3, Pln, Ppp2r3a, Rapgef4, Scn4b, Tnnc1, Tnni3 0-0-1-0-0-0 (MTi) Environmental Process NF-kappa B signaling pathway 19 2.4e-4 Bcl2l1, Ddx58, Gadd45b, Icam1, Ikbkb, Il1r1, Ly96, Malt1, Map3k14, Nfkb1, Nfkb2, Nfkbia, Pidd1, Relb, Tlr4, Tnfaip3, Tnfrsf1a, Tradd, Vcam1 0-0-1-0-0-0 (MTi) Environmental Process TNF signaling pathway 19 0.0027 Atf6b, Casp3, Casp7, Casp8, Creb3l1, Creb5, Fas, Icam1, Ikbkb, Map3k14, Map3k8, Mlkl, Nfkb1, Nfkbia, Rps6ka4, Tnfaip3, Tnfrsf1a, Tradd, Vcam1 0-0-1-0-0-0 (MTi) Organismal Systems Osteoclast differentiation 19 0.0055 Camk4, Fosb, Fosl1, Fosl2, Ifnar1, Ifnar2, Ikbkb, Il1r1, Irf9, Map3k14, Nfkb1, Nfkb2, Nfkbia, Relb, Stat2, Tgfb1, Tgfbr1, Tnfrsf1a, Tyk2 0-0-1-0-0-0 (MTi) Environmental Process MAPK signaling pathway 33 0.0062 Angpt2, Cacna1d, Casp3, Cdc25b, Dusp4, Dusp5, Dusp6, Egfr, Fas, Flna, Gadd45b, Hgf, Hspa1a, Igf1, Ikbkb, Il1r1, Il1rap, Map3k14, Map3k8, Mapk7, Met, Nfkb1, Nfkb2, Pla2g4a, Rap1b, Relb, Rps6ka4, Stk4, Taok3, Tgfb1, Tgfbr1, Tnfrsf1a, Tradd 0-0-1-0-0-0 (MTi) Organismal Systems IL-17 signaling pathway 13 0.0078 Casp3, Casp8, Ccl11, Fosb, Fosl1, Ikbkb, Mapk7, Mmp13, Nfkb1, Nfkbia, Tbk1, Tnfaip3, Tradd 0-0-1-0-0-0 (MTi) Organismal Systems NOD-like receptor signaling pathway 21 0.0093 Bcl2l1, Camp, Casp8, Ifi207, Ifnar1, Ifnar2, Ikbkb, Irf9, Nfkb1, Nfkbia, Oas1b, Oas1g, Oas2, Ripk2, Rnasel, Stat2, Tbk1, Tlr4, Tnfaip3, Txn1, Tyk2 0-0-1-0-0-0 (MTi) Organismal Systems C-type lectin receptor signaling pathway 14 0.019 Casp8, Cblb, Clec1b, Egr3, Ikbkb, Irf9, Malt1, Map3k14, Nfkb1, Nfkb2, Nfkbia, Plk3, Relb, Stat2 0-0-1-0-0-0 (MTi) Organismal Systems Th17 cell differentiation 13 0.022 Cd247, Gata3, Ikbkb, Il1r1, Il1rap, Irf4, Jak2, Nfkb1, Nfkbia, Rara, Tgfb1, Tgfbr1, Tyk2 0-0-1-0-0-0 (MTi) Environmental Process Cell adhesion molecules (CAMs) 15 0.022 Cd276, H2-Q7, Icam1, Itgav, Itgb8, Ncam1, Nectin1, Nfasc, Nrcam, Ptprf, Sdc3, Siglec1, Vcam1, Vcan, Vsir 0-0-1-0-0-0 (MTi) Environmental Process ECM-receptor interaction 11 0.035 Cd47, Col6a3, Col6a5, Gp1bb, Itga2, Itga2b, Itga5, Itgav, Itgb8, Thbs1, Thbs3 0-0-1-0-1-0 (MPi) Organismal Systems Antigen processing and presentation 34 8.8e-22 B2m, Cd4, Cd74, Ciita, Ctsb, Ctss, Gm11127, Gm8909, H2-Aa, H2-Ab1, H2-D1, H2-DMa, H2-DMb1, H2-DMb2, H2-Ea, H2-Eb1, H2-K1, H2-M3, H2-Q1, H2-Q10, H2-Q2, H2-Q4, H2-Q6, H2-T-ps, H2-T10, H2-T22, H2-T23, Hspa1b, Lgmn, Psme2, Psme2b, Tap2, Tapbp, Tnf 0-0-1-0-1-0 (MPi) Environmental Process Cell adhesion molecules (CAMs) 39 8.5e-18 Alcam, Cadm1, Cd22, Cd226, Cd4, Cd40, Cd6, Cd80, Cd86, Gm11127, Gm8909, H2-Aa, H2-Ab1, H2-D1, H2-DMa, H2-DMb1, H2-DMb2, H2-Ea, H2-Eb1, H2-K1, H2-M3, H2-Q1, H2-Q10, H2-Q2, H2-Q4, H2-Q6, H2-T-ps, H2-T10, H2-T22, H2-T23, Itga4, Itgam, Itgb2, Ptprc, Sdc1, Sele, Sell, Selplg, Spn 0-0-1-0-1-0 (MPi) Environmental Process Cytokine-cytokine receptor interaction 47 2.6e-17 Ccl12, Ccl9, Ccr2, Ccr5, Cd4, Cd40, Clcf1, Crlf2, Csf1r, Csf2ra, Csf2rb2, Csf3r, Cxcl1, Cxcl14, Cxcl16, Cxcr2, Gdf15, Gdf6, Il10ra, Il17ra, Il18, Il18rap, Il21r, Il2ra, Il2rb, Il2rg, Il3ra, Il4ra, Il6ra, Il7r, Inhba, Inhbb, Lif, Osmr, Pf4, Relt, Tgfb2, Tnf, Tnfrsf11a, Tnfrsf13b, Tnfrsf14, Tnfrsf1b, Tnfsf13, Tnfsf13b, Tnfsf14, Tnfsf9, Xcr1 0-0-1-0-1-0 (MPi) Organismal Systems NOD-like receptor signaling pathway 41 8.5e-14 Aim2, Birc3, Card9, Casp1, Casp12, Casp4, Ccl12, Ctsb, Cxcl1, Cyba, Cybb, Gbp3, Gbp7, Gsdmd, Ifi204, Ikbke, Il18, Irak4, Irf7, Myd88, Naip2, Naip5, Naip6, Nlrc4, Nlrp1b, Nod2, Oas1a, Oas3, P2rx7, Panx1, Plcb2, Prkcd, Pstpip1, Pycard, Ripk1, Ripk3, Stat1, Sting1, Tnf, Trpm2, Trpv2 0-0-1-0-1-0 (MPi) Environmental Process Viral protein interaction with cytokine and cytokine receptor 21 3.2e-10 Ccl12, Ccl9, Ccr2, Ccr5, Csf1r, Cxcl1, Cxcl14, Cxcr2, Il10ra, Il18, Il18rap, Il2ra, Il2rb, Il2rg, Il6ra, Pf4, Tnf, Tnfrsf14, Tnfrsf1b, Tnfsf14, Xcr1 0-0-1-0-1-0 (MPi) Organismal Systems Complement and coagulation cascades 20 4.7e-10 Bdkrb2, C1qa, C1qb, C1qc, C1ra, C1rb, C1s1, C2, C3, C3ar1, C4b, C5ar1, C6, Cfb, Clu, F5, Itgam, Itgb2, Plau, Serpine1 0-0-1-0-1-0 (MPi) Organismal Systems Osteoclast differentiation 30 8e-10 Acp5, Blnk, Btk, Csf1r, Ctsk, Cyba, Fcgr1, Fcgr2b, Fcgr3, Gm14548, Gm15448, Itgb3, Lck, Lcp2, Lilra6, Ncf2, Pik3cd, Pirb, Plcg2, Sirpa, Sirpb1a, Sirpb1c, Spi1, Stat1, Syk, Tgfb2, Tnf, Tnfrsf11a, Trem2, Tyrobp 0-0-1-0-1-0 (MPi) Organismal Systems Natural killer cell mediated cytotoxicity 24 9.7e-10 Bid, Cd48, Fcer1g, H2-D1, H2-K1, H2-T23, Hcst, Itgb2, Klrk1, Lat, Lck, Lcp2, Pak1, Pik3cd, Plcg2, Prkcb, Ptk2b, Ptpn6, Rac2, Sh3bp2, Syk, Tnf, Tyrobp, Vav1 0-0-1-0-1-0 (MPi) Environmental Process NF-kappa B signaling pathway 24 2.2e-8 Birc3, Blnk, Btk, Card14, Cd14, Cd40, Cxcl1, Irak4, Lat, Lbp, Lck, Lyn, Myd88, Plau, Plcg2, Prkcb, Ripk1, Syk, Ticam2, Tnf, Tnfrsf11a, Tnfsf13b, Tnfsf14, Traf1 0-0-1-0-1-0 (MPi) Environmental Process TNF signaling pathway 19 2.9e-4 Bcl3, Birc3, Ccl12, Cebpb, Cxcl1, Gm5431, Irf1, Lif, Mmp14, Mmp9, Nod2, Pik3cd, Ripk1, Ripk3, Sele, Tnf, Tnfrsf1b, Traf1, Vegfd 1-0-1-0-1-0 (EPi) Environmental Process Cytokine-cytokine receptor interaction 21 4.4e-19 Ccl2, Ccl3, Ccl5, Ccl6, Ccl7, Ccl8, Ccr1, Csf2rb, Cxcl10, Cxcl13, Cxcl5, Cxcl9, Cxcr6, Il18r1, Il1a, Il1b, Il1f9, Il1rn, Il33, Ltb, Osm 1-0-1-0-1-0 (EPi) Environmental Process Viral protein interaction with cytokine and cytokine receptor 12 6.4e-14 Ccl2, Ccl3, Ccl5, Ccl6, Ccl7, Ccl8, Ccr1, Cxcl10, Cxcl13, Cxcl5, Cxcl9, Il18r1 1-0-1-0-1-0 (EPi) Organismal Systems Chemokine signaling pathway 15 3.1e-12 Ccl2, Ccl3, Ccl5, Ccl6, Ccl7, Ccl8, Ccr1, Cxcl10, Cxcl13, Cxcl5, Cxcl9, Cxcr6, Fgr, Hck, Ncf1 1-0-1-0-1-0 (EPi) Environmental Process TNF signaling pathway 10 2.3e-8 Ccl2, Ccl5, Cxcl10, Cxcl5, Ifi47, Il18r1, Il1b, Junb, Mmp3, Socs3